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目的;考察茶碱控释胶囊(TPCC)释放度与体内的相关性.方法:应用ZRS-4溶出度仪测定TPCC的释放度.采用紫外分光光度法对8名健康受试者单剂量po TPCC 400 mg测定经时血药浓度,并按照Wagner-Nelson公式计算药物吸收分数.结果:体外释放度与体内吸收分数的相关系数为r=0.969 4.结论:TPCC片体外溶出度与体内吸收具有良好相关性.
Objective To investigate the release of the theophylline controlled release capsules (TPCC) in vivo.Methods: The release of TPCC was determined by ZRS-4 dissolution apparatus.Ultraviolet spectrophotometry was used to measure the concentration of single-dose po TPCC 400 mg was used to determine the concentration of drug on the passage of time, and the drug absorption fraction was calculated according to Wagner-Nelson formula.Results: The correlation coefficient between in vitro release and in vivo absorption fraction was r = 0.969 4. Conclusion: TPCC tablets have good in vitro dissolution and in vivo absorption Correlation.