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IL-2是最早被称为T细胞生长因子的蛋白质.它是免疫反应过程中释放的一系列淋巴因子中的一个重要因子.它的活性主要促使与抗原成致分裂原反应后的活化T细胞进行长远的增殖;另外,它还在其它类型细胞的增殖和成熟过程中起着直接或间接的作用.据发现,IL-2产生的不足发生于某些免疫缺损疾病中,如激活后的系统性红斑狼疮病人外周血T淋巴细胞生成IL-2的能力明显低下.这在一定意义上表明IL-2在人类免疫应答的完全表达中具有重要的意义. 近几年来IL-2广泛用于T细胞亚群和天然杀伤细胞(NK)的克隆,这向人们表明了它的一种潜在用途:即通过系统地转移扩增的淋巴细胞来达到对癌形成进行特异的被动免疫治
IL-2 is the earliest known protein of T-cell growth factor, which is an important factor in a series of lymphokines released during the immune response and its activity mainly promotes the activation of activated T cells In addition, it also plays a direct or indirect role in the proliferation and maturation of other types of cells.It has been found that the deficiency of IL-2 occurs in some immunodeficiency diseases, such as the activated system IL-2 in peripheral blood of patients with lupus erythematosus is significantly lower than that of IL-2, indicating that IL-2 is of great significance in the complete expression of human immune response in a certain sense.In recent years, IL-2 has been widely used in T The cloning of cell subsets and natural killer (NK) cells has shown one of its potential uses: to systematically transfer expanded lymphocytes to achieve specific passive immunotherapy against carcinogenesis