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静脉注射小檗碱(Ber)1～4mg/kg显著降低缺血再灌注心律失常的发生率,明显抑制心肌 LPO含量的异常升高。Ber 1,3和 10μmol/L使肛尾肌 Phe量效曲线平行右移、最大反应不变,log(x-1)对-log[B]作图的回归斜率为-1.06,表现为竞争性拮抗作用;但使心肌Phe量效曲线左移。Ber 30μmol/L明显抑制缺氧再给氧所致迟后除极,完全消除异常电活动。故Ber抗缺血再灌注心律失常作用的重要机理在于阻止心肌氧
Intravenous injection of berberine (Ber) 1 ~ 4mg/kg significantly reduced the incidence of arrhythmia after ischemia-reperfusion, significantly inhibited the abnormal increase of myocardial LPO content. Ber 1, 3, and 10 μmol/L paralleled the rightward shift of the Phe dose-response curve of the anal muscle, and the maximal response remained unchanged. The regression slope of log(x-1) versus log[B] was -1.06, indicating that it was competitive. Antagonism; but left the myocardial Phe dose-effect curve to the left. Ber 30 μmol/L significantly inhibited late depolarization caused by hypoxia and reoxygenation, completely eliminating abnormal electrical activity. Therefore, the important mechanism of Ber’s anti-arrhythmic effect of ischemia reperfusion is to prevent myocardial oxygen