HIV/AIDS患者免疫激活相关分子的表达及其对疾病进程的影响

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目的探讨HIV/AIDS患者外周血免疫激活相关分子的表达特征,分析其与艾滋病疾病进程的相关性。方法采用流式细胞仪检测80例HIV/AIDS患者和20例健康人外周血T淋巴细胞亚群及CD8+T淋巴细胞表面CD38、HLA-DR、Ki67分子的表达水平,比较健康人群与HIV/AIDS患者以及HIV/AIDS患者不同CD4+T分组间CD38+/CD8+、HLA-DR+/CD8+、Ki67+/CD8+的差异,分析CD8+T淋巴细胞CD38、HLA-DR、Ki67分子表达与CD4+T淋巴细胞及病毒载量之间的相关性。结果与健康人群相比,HIV/AIDS患者CD38+/CD8+、HLA-DR+/CD8+、Ki67+/CD8+明显升高(P<0.05);HIV/AIDS患者不同CD4+T分组间比较显示,随着CD4+T水平的降低,CD38+/CD8+、HLA-DR+/CD8+、Ki67+/CD8+逐渐升高,且艾滋病患者(CD4<200 cells/ml)明显低于慢性进展者(CD4≥200 cells/ml);CD38+/CD8+、HLA-DR+/CD8+、Ki67+/CD8+与血浆病毒载量均呈明显正相关。结论HIV感染能明显提高外周血CD38、HLA-DR和Ki67等分子的表达水平,且随着艾滋病疾病的进展,CD38、HLA-DR和Ki67的表达逐步升高,免疫系统异常激活的不断加剧与艾滋病疾病进程密切相关。 Objective To investigate the expression of immune activation-related molecules in peripheral blood of HIV / AIDS patients and analyze their correlation with the progression of AIDS. Methods The expression of CD38, HLA-DR and Ki67 on peripheral blood T lymphocyte subsets and CD8 + T lymphocytes in 80 HIV / AIDS patients and 20 healthy people were detected by flow cytometry. The differences of CD38 + / CD8 +, HLA-DR + / CD8 +, Ki67 + / CD8 + between different AIDS patients and HIV / AIDS patients were analyzed. The expressions of CD38, HLA-DR and Ki67 in CD8 + T lymphocytes and CD4 + T lymphocytes And the correlation between viral load. Results Compared with healthy controls, HIV / AIDS patients had significantly higher levels of CD38 + / CD8 +, HLA-DR + / CD8 + and Ki67 + / CD8 + (P <0.05) T level, and the level of CD38 + / CD8 +, HLA-DR + / CD8 + and Ki67 + / CD8 + were gradually increased in patients with AIDS (CD4 <200 cells / ml) CD8 +, HLA-DR + / CD8 +, Ki67 + / CD8 + were positively correlated with plasma viral load. Conclusion HIV infection can significantly increase the expression of CD38, HLA-DR and Ki67 in peripheral blood. With the progress of AIDS, the expression of CD38, HLA-DR and Ki67 gradually increase, and the abnormal activation of the immune system continues to increase. The AIDS disease process is closely related.
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