论文部分内容阅读
为探讨胃溃宁胶囊(WKN)的作用机理,指导临床用药。方法:进行消炎痛型、慢性醋酸型、幽门结扎型和应激型胃溃疡模型的实验及安全试验。结果:WKN对4种胃溃疡模型都有极显著的抗溃疡作用(P<0.01),对幽门结扎型胃溃疡可降低胃总酸度(P<0.01)和抑制胃酶活性(P<0.05),WKN无明显毒副作用。结论:WKN对实验性胃溃疡安全有效,可用于临床,作用机理是抑制或中和胃酸,抑制胃酶活性等。
To explore the mechanism of action of Weikuoning capsule (WKN) and guide clinical medication. METHODS: Experiments and safety tests were performed on models of indomethacin, chronic acetic acid, pylorus ligation, and stress gastric ulcers. RESULTS: WKN had extremely significant anti-ulcer effects on the four gastric ulcer models (P<0.01), and the pylorus-ligated gastric ulcer reduced gastric acidity (P<0.01) and inhibited gastric enzyme activity (P<0.05). WKN has no obvious toxic side effects. Conclusion: WKN is safe and effective for experimental gastric ulcer and can be used clinically. Its mechanism of action is to inhibit or neutralize gastric acid and inhibit gastric enzyme activity.