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目的检测胃溃疡组织中热休克蛋白70(HSP70)的表达,探讨其与胃溃疡发生发展的关系。方法采用免疫组化(SP法)方法,对48例经胃镜确诊的胃溃疡患者的胃镜活组织检查标本行HSP70的检测,分析其表达水平,并与对照组20例慢性浅表性胃炎患者病变部位活检标本检测结果作比较。结果胃溃疡组中有19例(39.6%)为阳性,HSP70在该组中表达水平较低,而对照组中HSP70阳性表达15例(75.0%),两组的表达差异有统计学意义(P<0.05)。结论HSP70低表达与胃溃疡发生发展有一定的相关性,HSP70表达减少可能提示了胃溃疡的发生发展。
Objective To detect the expression of heat shock protein 70 (HSP70) in gastric ulcer tissue and to explore its relationship with the development of gastric ulcer. Methods Immunohistochemistry (SP method) 48 cases of gastric ulcer patients diagnosed by gastroscopic biopsy specimens HSP70 detection, analysis of its expression level and compared with the control group of 20 patients with chronic superficial gastritis lesions The results of biopsy specimens were compared. Results In gastric ulcer group, 19 cases (39.6%) were positive, HSP70 expression was low in this group, and 15 cases (75.0%) in control group, the difference was statistically significant (P <0.05). Conclusions The low expression of HSP70 has a certain correlation with the occurrence and development of gastric ulcer. The decrease of HSP70 expression may indicate the occurrence and development of gastric ulcer.