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目的:探讨IL-17与IL-23在支气管哮喘患者血清中的表达水平及其相关性。方法:选择2010年2月~2015年9月在我院进行诊治的支气管哮喘患者98例,其中包括56例为缓解期组,42例为急性发作期组,对照组为20例体检健康者,观察三组的血清IL-17、IL-23水平及肺功能指标的差异,并分析其相关性。结果:与对照组相比,缓解期组和急性发作期组血清IL-17、IL-23水平均明显升高(P<0.05),急性发作期组血清IL-17、IL-23水平均显著高于缓解期组(P<0.05);急性发作期组患者的PEF%、FEV1%、V50%、V25%均明显低于缓解期组,差异有统计学意义(P<0.05);哮喘患者血清IL-17水平与IL-23水平呈正相关(r=0.685,P=0.000),血清IL-17与FEV1负相关(r=-0.592,P=0.000)、与PEF负相关(r=-0.515,P=0.000),IL-23与FEV1负相关(r=-0.598,P=0.000),与PEF负相关(r=-0.532,P=0.000)。结论:血清IL-17和IL-23的高表达可能参与了支气管哮喘的形成,并能影响疾病的进程,两者表达水平密切相关。
Objective: To investigate the expression of IL-17 and IL-23 in the serum of patients with bronchial asthma and its correlation. Methods: A total of 98 patients with bronchial asthma who were diagnosed and treated in our hospital from February 2010 to September 2015 were selected. Among them, 56 patients were remission group, 42 patients were acute exacerbation group, 20 patients in control group were healthy, The levels of serum IL-17, IL-23 and pulmonary function indexes in the three groups were observed and analyzed. Results: Compared with the control group, the levels of IL-17 and IL-23 in remission group and acute exacerbation group were significantly increased (P <0.05), and the levels of IL-17 and IL-23 in acute exacerbation group were significantly (P <0.05). PEF%, FEV1%, V50% and V25% of acute exacerbation group were significantly lower than that of remission group, the difference was statistically significant (P <0.05); Asthma patients serum The level of IL-17 was positively correlated with IL-23 level (r = 0.685, P = 0.000), serum IL-17 was negatively correlated with FEV1 (r = -0.592, P = 0.000) There was a negative correlation between IL-23 and FEV1 (r = -0.598, P = 0.000) and negatively correlated with PEF (r = -0.532, P = 0.000). Conclusion: High expression of serum IL-17 and IL-23 may be involved in the formation of bronchial asthma, and can affect the course of the disease, the expression level of the two are closely related.