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目的比较检测类风湿关节炎(RA)患者血清中的类风湿因子(RF)与抗环瓜氨酸肽抗体(抗-CCP抗体),探讨RA的早期诊断方法。方法对已确诊的42例RA患者、51例非RA的自身免疫病患者同时测定RF和抗CCP抗体,并对检测结果进行比较。结果42例RA患者中,抗-CCP抗体和RF对RA诊断的灵敏度分别为54.7%,65.3%,特异性分别为96.1%,73.4%。抗-CCP抗体的特异性比RF高,但敏感性比RF低。结论RF对RA具有较好的敏感性,抗-CCP抗体对RA具有高度的特异性,联合检测RF与抗-CCP抗体对RA患者的早期诊断具有非常重要的价值。
Objective To compare the serum levels of rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibody (anti-CCP antibody) in patients with rheumatoid arthritis (RA) and explore the early diagnosis of RA. Methods RF and anti-CCP antibodies were simultaneously assayed in 42 patients with RA and 51 patients with non-RA autoimmune diseases and the results were compared. Results The sensitivity of anti-CCP antibody and RF in diagnosing RA was 54.7% and 65.3% respectively in 42 RA patients, and the specificity was 96.1% and 73.4% respectively. Anti-CCP antibodies are more specific than RF, but less sensitive than RF. Conclusion RF has good sensitivity to RA. Anti-CCP antibody has high specificity for RA. Combined detection of RF and anti-CCP antibody is of great value in the early diagnosis of RA.