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目的通过对2001~2011年南阳市中心医院急性心肌梗死(AMI)患者的院内用药分析,探讨10年间AMI患者院内用药的变化趋势,为AMI患者合理用药提供参考。方法随机选择该院2001、2006、2011年间AMI患者住院病历,提取详细临床信息,分析AMI患者阿司匹林、氯吡格雷、他汀、血管紧张素转换酶抑制剂(ACEI)/血管紧张素受体桔杭药(ARB)及β受体阻滞剂的使用情况及其变化趋势。结果共收集AMI病历234份,结果显示:2001~2011年,阿司匹林、氯吡格雷及他汀的应用率增加,差异具有统计学意义(阿司匹林:2001年80.0%,2006年86.0%,2011年94.8%,P=0.013;氯吡格雷2001年0.0%,2006年50.9%,2011年87.8%,P<0.001;他汀2001年34.0%,2006年81.8%,2011年95.6%,P<0.001),β受体阻滞剂和ACEI/ARB类药物应用率仍比较低,且10年间变化无统计学差异(β阻滞剂2001年51.1%,2006年64.7%,2011年56.4%,P=0.401;ACEI类药物2001年62.5%,2006年72.2%,2011年60.9%,P=0.262)。结论过去10年间,南阳市中心医院AMI患者,阿司匹林、氯吡格雷及他汀使用率明显增加,β受体阻滞剂和ACEI/ARB类药物的使用仍与指南存在一定差距。
Objective To analyze the change of inpatient medication in patients with acute myocardial infarction (AMI) in Nanyang Central Hospital from 2001 to 2011, and to explore the trend of inpatients with AMI in 10 years. Methods The clinical data of patients with AMI in our hospital from 2001 to 2006 and 2011 were randomly selected, and detailed clinical information was extracted to analyze the relationship between aspirin, clopidogrel, statins, angiotensin converting enzyme inhibitor (ACEI) and angiotensin receptor Drug usage (ARB) and β-blockers and their trends. Results A total of 234 AMI cases were collected. The results showed that the rates of aspirin, clopidogrel and statin increased from 2001 to 2011, with statistical significance (aspirin: 80.0% in 2001, 86.0% in 2006 and 94.8% in 2011) , P = 0.013; Clopidogrel 2001 0 0%, 2006 50.9%, 2011 87.8%, P <0.001; statin 2001 34.0%, 2006 81.8%, 2011 95.6%, P <0.001) Body blockers and ACEI / ARB drug use rates are still relatively low, and 10 years was no significant difference (β blockers 51.1% in 2001, 64.7% in 2006, 56.4% in 2011, P = 0.401; ACEI class Drugs 62.5% in 2001, 72.2% in 2006, 60.9% in 2011, P = 0.262). Conclusion In the past 10 years, the use of aspirin, clopidogrel and statin in patients with AMI in Nanyang Central Hospital increased significantly. The use of β-blockers and ACEI / ARB drugs still lags behind the guidelines.