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吡哌酸(pipemide acid,PPA)是日本于1975年化学合成为吡酮酸类抗菌药物,我国于1980年研制成功,并应用于临床。该药具有抗菌谱较广,口服易吸收,疗效肯定,毒副作用小等优点,近年来应用日趋广泛。一、肠道感染 1.PPA或PPA+TMP治疗急性菌痢的疗效相当满意。PPA对痢疾杆菌具有抗菌作用,口服后肠道吸收好,并能透过肠粘膜,在肠腔内,血液及组织内均能达有效浓度。有文献报道,对氯霉素,氨苄青霉素耐药菌引起的小儿菌痢40例,经PPA治疗5～7天,有效率为92.5％。将PPA与TMP合用(PPA,1.0g,TMP
Pipemidic acid (PPA) is a chemical synthesized in Japan in 1975 for the pyrazolonic acid antibacterial drugs, developed in China in 1980 and applied to clinical. The drug has broad antibacterial spectrum, oral absorption, efficacy is positive, the advantages of small side effects, in recent years, the increasingly widespread use. First, the intestinal infection 1. PPA or PPA + TMP treatment of acute bacillary dysentery quite satisfied. PPA has an antibacterial effect on dysentery bacilli, intestinal absorption after oral administration, and through the intestinal mucosa, in the intestine, blood and tissue can reach an effective concentration. It has been reported in the literature that 40 cases of pediatric schistosomiasis caused by chloramphenicol and ampicillin-resistant bacteria were treated with PPA for 5 to 7 days with an effective rate of 92.5%. PPA and TMP combined (PPA, 1.0g, TMP