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目的:探讨二甲双胍联合甘精胰岛素治疗2型糖尿病的疗效研究。方法:56例体重指数(BMI)>24kg·m~(-2)的2型糖尿病患者随机分为两组,对照组26例在饮食控制和体育锻炼基础上,给予甘精胰岛素皮下注射;观察组30例在对照组治疗基础上加服二甲双胍片0.85 g,po bid。治疗12周,分别观察两组胰岛素用量、BMI、糖化血红蛋白(HbAlc)、空腹血糖(FPG)及餐后2h血糖水平。结果:与治疗前相比,两组治疗后HbAlc、FPG及餐后2h血糖均明显下降(P<0.05),两组胰岛素用量及治疗后BMI比较,差异有统计学意义(P<0.05);HbAlc稍有差异,但无统计学意义(P>0.05)。结论:二甲双胍联合甘精胰岛素能较好的控制血糖达标,有效改善代谢紊乱;加用二甲双胍可明显减少甘精胰岛素用量,改善胰岛素抵抗。
Objective: To investigate the curative effect of metformin combined with insulin glargine on type 2 diabetes mellitus. Methods: Fifty-six patients with type 2 diabetes who had a body mass index (BMI)> 24 kg · m -2 were randomly divided into two groups. The control group received subcutaneous injection of insulin glargine on the basis of diet control and physical activity. Group 30 patients in the control group based on the treatment plus metformin tablets 0.85 g, po bid. After 12 weeks of treatment, the levels of insulin, BMI, HbAlc, fasting blood glucose (FPG) and 2h postprandial blood glucose were observed. Results: Compared with those before treatment, HbA1c, FPG and 2h postprandial blood glucose were significantly decreased in both groups (P <0.05). There was significant difference between the two groups in insulin dosage and BMI after treatment (P <0.05). HbAlc slightly different, but not statistically significant (P> 0.05). CONCLUSION: Metformin combined with insulin glargine can better control blood sugar level and effectively improve metabolic disorder. Metformin can be used to reduce the dosage of insulin glargine and improve insulin resistance.