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目的:探讨肺功能正常人群吸烟状况和气道炎症因子的表达谱。方法:依据肺功能采用主成分分析和聚类分析方法将健康人群分类,从吸烟状况、诱导痰细胞因子表达谱的角度探讨各组间临床特征。结果:肺功能正常人群可以分为总体肺功能下降组、大气道功能下降组、小气道功能下降组和肺功能良好组。4组人群吸烟状况、诱导痰TGF-β1表达水平存在差异(P<0.05)。结论:依据4种分型的各自特点,可为COPD的早期诊断和干预治疗提供新的思路。
Objective: To investigate the smoking status and expression profile of airway inflammatory factors in normal lung function population. Methods: According to the pulmonary function, principal component analysis and cluster analysis were used to classify the healthy population. The clinical characteristics of each group were discussed from the aspects of smoking status and induced cytokines expression of sputum. Results: Normal lung function can be divided into general lung function decline group, airway function decline group, small airway function decline group and lung function good group. There were differences in smoking status and induced sputum TGF-β1 expression among the four groups (P <0.05). Conclusion: According to the characteristics of the four subtypes, we can provide new ideas for the early diagnosis and treatment of COPD.