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为探讨γ－谷氨酰移换酶（ＧＧＴ）糖链异质体对肝癌的诊断价值，以化学致癌剂２－ＦＡＡ诱发鼠肝脏癌变，对癌变过程中的肝脏组织ＧＧＴ总量及其ＧＧＴ糖链异质体进行动态观察。结果提示，肝癌组织ＧＧＴ总量明显高于对照组（Ｐ＜０．０１），ＧＧＴ活性随癌组织肿块的增大而增高；其肝癌组织中的ＧＧＴ对ＣｏｎＡ的亲和性也呈动态改变，随肝癌组织的肿块增大而呈持续下降，即ＣｏｎＡ非结合型ＧＧＴ（ＧＧＴ－Ｎ－Ｃ）持续增加。表明，ＧＧＴ－Ｎ－Ｃ含量检测有助于肝癌的早期诊断。
In order to investigate the diagnostic value of γ-glutamyl transferase (GGT) glycans heterogeneous on liver cancer, the total amount of GGT in liver tissue and its GGT sugars Chain heterozygotes for dynamic observation. The results showed that the total amount of GGT in hepatocellular carcinoma was significantly higher than that in control group (P <0.01), and the activity of GGT increased with the increase of tumor mass. The affinity of GGT to ConA in hepatocellular carcinoma was also changed dynamically, With the increase of tumor mass in hepatocellular carcinoma, the number of ConA non-binding GGT (GGT-N-C) continued to increase. Show that the detection of GGT-N-C contribute to the early diagnosis of liver cancer.