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目的探讨抗Jo-1抗体与特发性炎症性肌病左心室功能的相关性。方法纳入2006年至2013年我院收治的特发性炎症性肌病患者69例。运用酶联免疫法检测抗Jo-1抗体,同时采用超声心动图检查左心室功能,最后使用多因素线性回归分析评估抗Jo-1抗体与特发性炎症性肌病患者左心室功能的关系。结果特发性炎症性肌病患者左心室舒张功能不全发生率为76.81%,抗Jo-1抗体阳性率为18.84%,抗Jo-1抗体阳性患者病程较长(p=0.007),间质性肺病(p=0.002)和雷诺现象(p=0.006)发生比例较高,同时,这些患者二尖瓣舒张早期峰值速度值/二尖瓣瓣环舒张早期峰值速度比值较大(p=0.001),但收缩功能指标无明显差异。多因素分析显示抗Jo-1抗体与左心室舒张功能密切相关。结论抗Jo-1抗体阳性与特发性炎症性肌病左心室舒张功能不全密切相关,但具体机制仍然需要进一步研究。
Objective To investigate the correlation between anti-Jo-1 antibody and left ventricular function in idiopathic inflammatory myopathies. Methods Sixty-nine patients with idiopathic inflammatory myopathies admitted to our hospital from 2006 to 2013 were enrolled. The anti-Jo-1 antibody was detected by enzyme-linked immunosorbent assay, left ventricular function was examined by echocardiography, and the relationship between anti-Jo-1 antibody and left ventricular function in patients with idiopathic inflammatory myopathy was evaluated by multivariate linear regression analysis. Results The incidence of left ventricular diastolic dysfunction was 76.81% in patients with idiopathic inflammatory myopathy, the positive rate of anti-Jo-1 antibody was 18.84%, the duration of anti-Jo-1 antibody positive patients was longer (p = 0.007), interstitial Pulmonary disease (p = 0.002) and Raynaud’s phenomenon (p = 0.006) were associated with higher rates of peak mitral diastolic early / mitral annular early diastolic peak velocity (p = 0.001) However, there was no significant difference in systolic function. Multivariate analysis showed that anti-Jo-1 antibody was closely related to left ventricular diastolic function. Conclusion The positive anti-Jo-1 antibody is closely related to left ventricular diastolic dysfunction in idiopathic inflammatory myopathy, but the specific mechanism still needs further study.