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目的：提高对多发性硬化（ＭＳ）的临床与ＭＲＩ表现的认识。方法：回顾性分析５０例临床确诊的ＭＳ的临床与ＭＲＩ表现及临床定位与ＭＲＩ定位的关系。结果：５０例ＭＳ在ＭＲＩ上均发现病灶，ＭＲＩ可显示临床上无定位体征的大脑半球上的亚临床病灶，对临床上有定位体征的脑干、小脑、脊髓的病灶可全部显示，对视神经病变显示欠佳。ＭＳ斑块在Ｔ２ＷＩ均为高信号，在Ｔ１ＷＩ为等或低信号，急性期病灶周边明显强化，激素治疗后病灶明显减少并缩小。结论：ＭＲＩ对显示视神经以外的ＭＳ病灶高度敏感，并可显示临床上无定位体征的亚临床病灶，为ＭＳ临床诊断提供可靠依据，可作为确诊ＭＳ的首选检查方法。
OBJECTIVE: To raise awareness of the clinical and MRI findings of multiple sclerosis (MS). Methods: The clinical and MRI features of 50 clinically diagnosed MS patients were retrospectively analyzed. The relationship between clinical location and MRI location was analyzed. Results: 50 cases of MS were found on MRI lesions, MRI can show clinically without signs of sub-clinical lesions on the hemisphere, the clinical signs of the brain stem, cerebellum, spinal cord lesions can be fully displayed on the optic nerve Lesions show poor. MS plaques in T2WI are high signal, equal or low signal in the T1WI, acute lesions significantly enhanced peripheral lesions significantly reduced and reduced after hormone therapy. Conclusion: MRI is highly sensitive to MS lesions outside the optic nerve and can show subclinical lesions without clinical signs. It can provide a reliable basis for the clinical diagnosis of MS and can be used as the first choice for the diagnosis of MS.