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目的探讨苏黄止咳胶囊辅助治疗咳嗽变异性哮喘(CVA)的临床疗效。方法选取2014年1月—2015年1月公安县人民医院收治的CVA患者80例,随机分为观察组与对照组,各40例。对照组患者予以沙美特罗替卡松粉吸入剂治疗,观察组患者在对照组基础上加用苏黄止咳胶囊治疗。观察两组患者治疗前后咳嗽症状积分(日间咳嗽积分、夜间咳嗽积分)、肺功能指标〔第1秒用力呼气容积(FEV1)、第1秒用力呼气容积占肺活量的百分比(FEV1/FVC)〕、诱导痰嗜酸细胞(EOS)百分比及不良反应发生情况。结果治疗前两组患者日间咳嗽积分、夜间咳嗽积分比较,差异无统计学意义(P>0.05),治疗后观察组患者日间咳嗽积分、夜间咳嗽积分低于对照组,差异有统计学意义(P<0.05);治疗前两组患者FEV1、FEV1/FVC比较,差异无统计学意义(P>0.05),治疗后观察组患者FEV1、FEV1/FVC高于对照组,差异有统计学意义(P<0.05);治疗前两组患者诱导痰EOS百分比比较,差异无统计学意义(P>0.05),治疗后观察组患者诱导痰EOS百分比低于对照组,差异有统计学意义(P<0.05);两组患者均未发生严重不良反应。结论苏黄止咳胶囊辅助治疗咳嗽变异性哮喘的临床疗效显著,可缓解患者咳嗽,改善患者肺功能,降低诱导痰EOS百分比,且不良反应少。
Objective To investigate the clinical effect of Su Huang Zhi Ke Capsule in the treatment of cough variant asthma (CVA). Methods From January 2014 to January 2015, 80 cases of CVA patients admitted to Gong’an People’s Hospital were randomly divided into observation group and control group, 40 cases in each group. Patients in the control group were treated with salmeterol and fluticasone propionate inhalation. Patients in the observation group were treated with Suhuangzhike Capsules on the basis of the control group. Cough symptom score (daytime cough score, nighttime cough score), pulmonary function index (FEV1), forced expiratory volume in 1 second as a percentage of vital capacity (FEV1 / FVC )〕, Induced sputum eosinophil (EOS) percentage and the incidence of adverse reactions. Results Before treatment, daytime cough scores and nighttime cough scores were not significantly different between the two groups (P> 0.05). After treatment, the scores of daytime cough scores and nighttime cough scores in the observation group were lower than those in the control group, the difference was statistically significant (P <0.05). There was no significant difference in FEV1 and FEV1 / FVC between the two groups before treatment (P> 0.05). FEV1 and FEV1 / FVC in the observation group were significantly higher than those in the control group after treatment P <0.05). There was no significant difference in the percentage of EOS induced sputum between the two groups before treatment (P> 0.05), and the percentage of EOS induced sputum in the observation group was lower than that of the control group after treatment ); No serious adverse reactions occurred in both groups. Conclusion Suhuangzhike Capsule has the significant clinical curative effect in the treatment of cough variant asthma, which can relieve the cough, improve the lung function and reduce the percentage of induced sputum EOS with less adverse reactions.