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目的:应用人重组白细胞介素(rhIL—2)配合常规药物治疗兔单纯疱疹病毒性角膜炎(HSK)预防复发。方法:给兔接种HSV前十天应用rhIL-2提高免疫功能治疗,待形成HSK后配合常规药物治疗,同时设对照组。应用PCR技术检测观察兔感染HSV体内动态变化,依据HSK诊断标准观察其疗效。结果:实验组与对照组相比有延长潜伏感染期、发病轻、病程短恢复快效果,HSV在三叉神经节潜伏率低。结论:应用rhIL-2能治疗兔HSK和预防复发效果,无不良反应。
Objective: To prevent the recurrence of herpes simplex virus keratitis (HSK) with rhIL-2 and conventional drugs. Methods: Ten days before HSV inoculation, rhIL-2 was used to improve the immune function. After HSK was formed, the patients were treated with conventional drugs and the control group. The dynamic changes of HSV in rabbits infected with HSV were observed by PCR and the therapeutic effect was observed according to the diagnostic criteria of HSK. Results: Compared with the control group, the experimental group had the potential of prolonging latent infection, mild onset of disease and short course of recovery. The latent rate of HSV in trigeminal ganglion was low. Conclusion: rhIL-2 can treat rabbit HSK and prevent recurrence without adverse reactions.