约15～20%的十二指肠溃疡患者用H_2受体拮抗剂治疗无效。每天至少服1.0克甲氰咪胍,治疗2个月后仍有溃疡症状,且内窥镜证实溃疡未愈者可确认甲氰咪胍无效。这类患者往往较年轻,有较长的溃疡病史或家族史,溃疡一般较大,周围有较严重的十二指 About 15 to 20% of duodenal ulcer patients with H 2 receptor antagonist therapy ineffective. Cimetidine at least 1.0 grams per day, 2 months after treatment, there are still ulcer symptoms, and endoscopic confirmed ulcer hemorrhage can confirm cimetidine ineffective. Such patients are often younger, have a longer history of ulcers or family history, ulcers are generally larger, surrounded by more serious twelve fingers