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目的 :观察一氧化氮、TNFα与溃疡性结肠炎的关系。 方法 :采用硝酸还原酶法和生物素链亲和素 EL ISA法测定 40例溃疡性结肠炎患者和 40例正常人血清 NO和 TNFα。 结果 :1溃疡性结肠炎患者血清 NO浓度非常显著地高于正常人 (P<0 .0 1) ,阳性率为 85 % ;2溃疡性结肠炎患者 TNFα显著高于正常人 (P<0 .0 5 )。 结论 :血清 NO升高可作为溃疡性结肠炎检测的实验室指标。
Objective: To observe the relationship between nitric oxide, TNFα and ulcerative colitis. Methods: Nitric acid reductase method and streptavidin-streptavidin-streptavidin-linked immunosorbent assay were used to determine serum NO and TNFα in 40 patients with ulcerative colitis and 40 normal controls. Results: 1 Serum NO levels in patients with ulcerative colitis were significantly higher than those in normal controls (P <0.01), and the positive rate was 85%. 2 The levels of TNFα in patients with ulcerative colitis were significantly higher than those in controls (P <0. 0 5). Conclusion: Elevated serum NO can be used as a laboratory index for the detection of ulcerative colitis.