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目的探讨蔗糖铁注射液对纠正维持性血液透析患者的贫血疗效及微炎症状态的影响。方法选择血液透析患者98例,观察用药前后血红蛋白浓度、红细胞压积、血清铁、血清铁蛋白、转铁蛋白饱和度,以及血清C反应蛋白、白介素-1β、白介素-6、白介素-10、肿瘤坏死因子-α,并监测不良反应。结果8周后,治疗后血红蛋白水平及血清铁蛋白较治疗前明显改善(P<0.05或P<0.01);血浆及血清C反应蛋白、白介素-1β、肿瘤坏死因子-α均较治疗前显著升高(P<0.01或P<0.05)。其有效率达94.90%。仅出现2例轻微胃肠不适反应,1例轻微心悸和1例皮肤瘙痒。结论静脉补铁有效改善患者的贫血及缺铁,也加剧了其炎症状态。为针对其微炎症状态的干预治疗提供依据。
Objective To investigate the effect of sucrose iron injection on the treatment of anemia and the status of micro-inflammation in maintenance hemodialysis patients. Methods Hemoglobin concentration, hematocrit, serum iron, serum ferritin, transferrin saturation and serum C - reactive protein, interleukin - 1β, interleukin - 6, interleukin - 10, tumor Necrosis factor-α, and monitor adverse reactions. Results After 8 weeks, the levels of hemoglobin and serum ferritin were significantly improved (P <0.05 or P <0.01), and the plasma and serum C-reactive protein, interleukin-1β and tumor necrosis factor- High (P <0.01 or P <0.05). The effective rate of 94.90%. Only 2 cases of mild gastrointestinal upset reaction, 1 case of mild palpitations and 1 case of pruritus appeared. Conclusion Intravenous iron supplementation can effectively improve the patients’ anemia and iron deficiency, and aggravate the inflammatory state. To provide a basis for the intervention of its state of micro-inflammation treatment.