环孢菌素A(cyclosporin A, CyA)是同迄今所使用的免疫抑制药的作用机制完全不同的免疫抑制剂。它主要用于器官移植,并且取得极为良好的临床疗效。CyA主要作用于辅助性T细胞,能抑制它产生IL-1、IL-2和IFN等细胞因子,进而能特异性抑制细胞免疫功能。1980年以来在器官移植以外的领域中,CyA对广义的自身免疫病也有疗效。在适应证中,对自塞氏综合征的眼葡萄膜炎的疗效比其他疾病均好。日本用双盲法也肯定了其疗效。一、血液疾病1.单纯性红细胞再生不良(pure red cell aplasia, PRCA) PRCA只是红细胞系统造血障碍的疾病。先天性 Cyclosporin A (CyA) is a completely different immunosuppressant than the mechanism of action of immunosuppressants used to date. It is mainly used for organ transplantation, and achieved very good clinical efficacy. CyA mainly acts on helper T cells and inhibits the production of cytokines such as IL-1, IL-2 and IFN, thereby further specifically inhibiting cellular immune function. CyA has also been shown to be effective in a broad range of autoimmune diseases beyond organ transplantation since 1980. In indications, the self-Syndrome of Uveitis than other diseases are good. Japan’s double-blind method also affirmed its efficacy. First, the blood disease 1. Simple red cell aplasia (PRCA) PRCA is only a hematopoietic disorder of the erythrocyte disease. Congenital