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[目的]观察复方鳖甲软肝片联合阿德福韦酯(ADM)治疗慢性乙型肝炎(慢乙肝)肝纤维化疗效。[方法]慢乙肝患者48例,随机分为2组,每组24例,A组以复方鳖甲软肝片与阿德福韦酯联合治疗,B组单独以阿德福韦酯治疗。观察2组治疗前后丙氨酸氨基转移酶(ALT)、天冬氨酸转氨酶(AST)、胆红素(SB)的复常率及血清肝纤维化指标变化。[结果]治疗结束时,AST、SB复常率2组间差异有统计学意义(P<0.05),血清肝纤维化指标2组相比差异亦有统计学意义(P<0.05)。[结论]复方鳖甲软肝片联合阿德福韦酯治疗慢乙肝肝纤维化有较好疗效。
[Objective] To observe the curative effect of compound Biejia Ruangan Pian combined with adefovir dipivoxil (ADM) on chronic hepatitis B (chronic hepatitis B) hepatic fibrosis. [Method] Forty-eight patients with chronic hepatitis B were randomly divided into 2 groups (24 in each group). Group A was treated with Fufang Biejia Ruangan Pian and adefovir dipivoxil, while group B was treated with adefovir dipivoxil alone. The changes of ALT, AST and SB in the two groups before and after treatment were observed and the indexes of serum liver fibrosis were observed. [Results] At the end of treatment, there was a significant difference between the two groups in the normalization rate of AST and SB (P <0.05). There was also a significant difference between the two groups in serum liver fibrosis index (P <0.05). [Conclusion] Fufang Biejia Ruangan Pian combined with adefovir dipivoxil is effective in treating chronic hepatitis B liver fibrosis.