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目的探讨慢性阻塞性肺疾病急性加重期(AECOPD)患者住院期间发生静脉血栓栓塞症(VTE)的危险因素。方法对我院2011年12月~2014年8月因AECOPD入院患者按是否合并VTE分为合并VTE组和不合并VTE组,并对患者基本资料、临床表现、危险因素进行比较分析。结果共有822名AECOPD患者入组,合并VTE组203人,两组患者在性别比例、肺功能分级、是否卧床、是否合并肿瘤、近期手术或骨折病史几方面数据有明显统计学差异。结论 AECOPD患者常常合并VTE,肿瘤、卧床及FEV1/%pred(≤0.5)是其独立的危险因素,对合并2种或2种以上VTE危险因素的患者可常规进行抗凝治疗。
Objective To investigate the risk factors of venous thromboembolism (VTE) in hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods The hospitalized patients with AECOPD from December 2011 to August 2014 were divided into two groups based on whether they were combined with VTE or without VTE. The basic data, clinical manifestations and risk factors of patients with AECOPD were compared and analyzed. Results A total of 822 patients with AECOPD were enrolled in the study. There were 203 patients in the VTE group. There were significant differences between the two groups in terms of sex ratio, grade of lung function, bed rest, tumor consolidation, recent surgery or fracture history. Conclusions AECOPD patients are often associated with VTE, tumor, bed rest, and FEV1 /% pred (≤0.5) as independent risk factors for routine anticoagulation in patients with two or more risk factors for VTE.