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目的:探讨癌症晚期病人肠外营养(PN)再喂养综合征的预防方法。方法:选择癌症晚期病人86例,NRS 2002营养不良风险筛查评分≥3分,根据生化监测结果静脉给予电解质、肌内注射维生素B1和按阶梯行PN和液体入量。结果:血清磷、钾、镁第3天最低,与再喂养第1和第8天比均有显著性差异(P<0.05),第8天有>90%的病人恢复至正常值范围。再喂养综合征患病率为8.14%。结论:癌症晚期不能进食病人补充足够的维生素B1和电解质,同时行阶梯PN支持,可降低再喂养综合征的发生率。
Objective: To investigate the preventive methods of parenteral nutrition (PN) refeeding syndrome in advanced cancer patients. Methods: Eighty-six patients with advanced cancer and NRS 2002 malnutrition risk screening score ≥3 were selected. Electrolytes were given intravenously according to biochemical monitoring results. Vitamin B1 and PN and fluid were injected intramuscularly. Results: The serum phosphorus, potassium and magnesium were the lowest on the third day, compared with those on the first and eighth day of re-feeding (P <0.05). On the 8th day, more than 90% of the patients returned to the normal range. The prevalence of refeeding syndrome was 8.14%. CONCLUSIONS: In patients with advanced cancer, enough vitamin B1 and electrolytes can not be given to the patient, and a stepwise PN support can reduce the incidence of refeed syndrome.