从α-萘乙酸出发,合成酰基异硫氰酸酯,然后与2-氨基-5-芳基-1,3,4-二唑反应合成了8个新的酰基硫脲类化合物 a～ h。所有化合物的结构均经元素分析、红外光谱、核磁共振氢谱和质谱确认。同时对6种病原菌进行了生物活性测试,结果发现,在50mg/L下,所有目标化合物对黄瓜灰霉病菌Botrytiscinereapers的抑制效果较好,除 a外,其他化合物抑制率都达到80%以上。 Starting from α-naphthaleneacetic acid, acyl isothiocyanates were synthesized and then 8 new acyl thioureas were synthesized by reaction with 2-amino-5-aryl-1,3,4-oxadiazoles . The structures of all the compounds were confirmed by elemental analysis, IR, 1H-NMR and MS. At the same time, six kinds of pathogenic bacteria were tested for biological activity. The results showed that all the target compounds had good inhibitory effect on Botrytis cinereapers at 50mg / L, except for a, the inhibitory rates of other compounds reached more than 80%.