端粒 端粒酶假说是新近提出的肿瘤形成的新理论。端粒是真核细胞染色体末端的具有保持染色体的稳定功能的DNA 蛋白复合体 ,端粒酶是一种RNA依赖性的DNA聚合酶 ,端粒酶的激活使端粒长度得以稳定 ,细胞获得无限增殖能力 ,成为永生细胞 ,而获得永生性是细胞恶变的关键步骤。近年的研究表明测定肺癌各种标本的端粒酶活性不仅有助于肺癌的诊断 ,还可用于肺癌的恶性程度、病理分期及预后的判断。端粒酶有望成为有价值的肺癌诊断的标记物。 The telomere telomerase hypothesis is a newly proposed new theory of tumor formation. The telomere is a DNA protein complex with a stabilizing function that maintains chromosomes at the end of chromosomes of eukaryotic cells. Telomerase is an RNA-dependent DNA polymerase. Activation of telomerase stabilizes the telomere length, and the cells gain indefinitely. The ability to proliferate becomes an immortal cell, and obtaining immortality is a critical step in the malignant transformation of the cell. Recent studies have shown that measuring telomerase activity in various specimens of lung cancer not only contributes to the diagnosis of lung cancer, but also can be used to judge the degree of malignancy, pathological stage, and prognosis of lung cancer. Telomerase is expected to be a valuable marker for the diagnosis of lung cancer.