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目的探讨米非司酮配伍甲基睾丸素治疗围绝经期功能失调性子宫出血(功血)的临床效果。方法2006年1月至2007年1月梅州市计划生育服务中心确诊围绝经期功血患者28例,用小剂量米非司酮配伍小剂量甲基睾丸素治疗3个月,治疗前后B超测量子宫内膜厚度,检测肝肾功能及血常规,观察月经及围绝经期症状。结果28例患者内膜均变薄,血红蛋白均不同程度提高,肝肾功能均正常,用药期间均闭经,无明显绝经期症状。结论小剂量米非司酮配伍小剂量甲基睾丸素治疗围绝经期功血效果好,不良反应小,复发率低,是一种较理想的药物治疗方法。
Objective To investigate the clinical efficacy of mifepristone combined with methyltestosterone in treating peri-menopausal dysfunctional uterine bleeding (dysfunctional uterine bleeding). Methods From January 2006 to January 2007, Meizhou Family Planning Service Center diagnosed 28 cases of perimenopausal dysfunctional uterine bleeding, treated with low dose of mifepristone and low dose of methyltestosterone for 3 months. Before and after treatment, B ultrasonic measurement Endometrial thickness, liver and kidney function tests and blood tests to observe the menses and perimenopausal symptoms. Results All the 28 patients had thinning of the intima, hemoglobin increased to varying degrees, liver and kidney function were normal, amenorrhea during medication, no obvious symptoms of menopause. Conclusion Small dose of mifepristone combined with low-dose methyl testosterone for peri-menopausal dysfunctional uterine bleeding is effective, with small adverse reactions and low recurrence rate. It is an ideal drug treatment.