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目的了解甘肃省乙型肝炎(乙肝)病毒(Hepatitis B Virus,HBV)感染血清标志物的变化。方法对甘肃省1980、1992、2006年乙肝血清流行病学调查资料进行比较分析。结果甘肃省1～59岁人群乙肝病毒表面抗原(HBV Surface Antigen,HBsAg)阳性率由7.52%降至4.39%,1～9岁儿童HBsAg阳性率为1.66%,比1992年下降了77%;农村人群HBsAg阳性率均高于城市,城市人群HBsAg阳性率下降幅度大于农村;抗乙肝病毒表面抗原抗体(Antibody to HBsAg,Anti-HBs)阳性率由3.11%上升到49.48%,1992年随年龄增长而升高,2006年则随年龄增长而下降,1～9岁儿童Anti-HBs阳性率最高;HBV感染率和抗乙肝病毒核心抗原抗体(Antibody to HBVCore Antigen,Anti-HBc)阳性率均呈现随年龄的增长逐渐升高的趋势,但2006年的各年龄组人群HBV感染率和Anti-HBc阳性率均明显低于1992年。结论甘肃省1～59岁人群HBV感染率明显降低,乙肝疫苗免疫取得良好效果,尤其是针对儿童的免疫策略效果更为明显。
Objective To understand the changes of serum markers of Hepatitis B Virus (HBV) infection in Gansu Province. Methods The epidemiological survey of hepatitis B in Gansu Province in 1980, 1992 and 2006 were compared and analyzed. Results The positive rate of HBsAg was reduced from 7.52% to 4.39% in 1-59 year-olds in Gansu Province. The positive rate of HBsAg in children aged 1-9 years was 1.66%, down 77% from 1992; The positive rate of HBsAg in urban population was higher than that in urban areas, and the positive rate of HBsAg in urban population was lower than that in rural areas. The positive rate of anti-HBsAg antibody (Anti-HBsAg) increased from 3.11% to 49.48% While the level of Anti-HBs in children aged 1-9 was the highest. The positive rates of HBV infection and anti-HBc were all higher with age The trend of increasing gradually increased. However, the rates of HBV infection and anti-HBc in all age groups in 2006 were significantly lower than those in 1992. Conclusion The prevalence of HBV infection in people aged 1-59 years in Gansu province was significantly lower than that in other provinces. Hepatitis B vaccine achieved good results, especially for children.