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以乳酸环丙沙星（ＣＰＬＸ）注射液和氧氟沙星（ＯＦＬＸ）注射液随机分组治疗各种细菌性感染４０例及４２例，并以注射用头孢噻肟钠（ＣＴＸ）治疗４９例作对照。三组平均年龄、体重、疗程及病情程度相比无显著性差异，具可比性。病种分布以消化道感染最多，共８１例，占总数的６１．８％。三组１３１例病人细菌阳性率为９４．７％。一疗程ＣＰＬＸ组、ＯＦＬＸ组、ＣＴＸ组治愈率分别为８７．２％、８３．３％、７１．４％，有效率分别为８７．２％、９７．６％、８３；７％；细菌清除率分别为８９．２％、９７．４％、８９．８％。三组治愈率及细菌清除率比较无显著性差异，有效率比较Ｐ＜０．０５。体外抗菌活性检测示ＣＰＬＸ对伤寒沙门氏菌、痢疾志贺氏菌的ＭＩＣ卯均为０．１２μｇ／ｍｌ，ＯＦＬＸ则均为０．２５μｇ／ｍｌ。不良反应发生率三组分别为１５．０％、９．５％、１２．２％（ＰＬＸ组和ＯＦＬＸ组主要是静脉炎。本文结果表明乳酸环丙沙星注射液和氧氟沙星注射液是治疗多种细菌所致中、重度感染的安全有效的抗菌药物。
A total of 40 and 42 cases of various bacterial infections were randomly divided into two groups: injections of ciprofloxacin lactate (CPLX) and ofloxacin (OFLX) and injections of cefotaxime sodium (CTX) for 49 cases Control. There was no significant difference between the three groups in terms of average age, body weight, course of treatment and illness, which was comparable. The distribution of diseases with the most digestive tract infection, a total of 81 cases, accounting for 61.8% of the total. The positive rate of bacteria in 131 patients in three groups was 94.7%. The cure rates of CPLX group, OFLX group and CTX group during a course of treatment were 87.2%, 83.3% and 71.4%, respectively, and the effective rates were 87.2%, 97.6% and 83.7% respectively. Bacterial clearance Rates were 89.2%, 97.4%, 89.8% respectively. Three groups of cure rate and bacterial clearance rate no significant difference, the effective rate was P <0.05. In vitro antibacterial activity test showed that CPLX against Salmonella typhi, Shigella dysentery MIC d were 0.12μg / ml, OFLX were 0.25μg / ml. The incidences of adverse reactions in the three groups were 15.0%, 9.5% and 12.2%, respectively (PLX group and OFLX group were mainly phlebitis.) The results showed that ciprofloxacin lactate injection and ofloxacin injection Is the treatment of a variety of bacteria caused by moderate and severe infections of safe and effective antibacterial drugs.