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该文研究人参茎叶多糖、田七多糖、绞股兰皂甙、白花蛇舌草煎液对补体及经CVF处理的豚鼠补体活性的影响,发现上述中药成分对正常豚鼠补体水平无明显影响,但对经CVF处理后的豚鼠低补体状态在连续给药5～8天后有一定促进恢复作用。给豚鼠腹腔注射50μg/kg的CVF,CH_(50)下降94％～97％,12天后才恢复正常。此时再次给予同样剂量的CVF,几乎不能再产生降补体作用,可能是由于已产生CVF抗体的缘故。用CVF造成动物低补体状态以研究某些中药成分的药理作用是一新的尝试。
This study investigated the effects of ginseng stem-leaf polysaccharides, polysaccharides from Tianchi, Gynostemma saponins, and Hedyotis diffusa on the complement activity of complement and CVF-treated guinea pigs, and found that the above-mentioned Chinese herbal ingredients had no significant effect on the level of complement in normal guinea pigs. However, the low complement state of CVF-treated guinea pigs promoted recovery after 5-8 days of continuous administration. Intraperitoneal injection of 50μg/kg of CVF to guinea pigs, CH_ (50) decreased by 94% to 97%, and returned to normal 12 days later. At this time, the same dose of CVF was administered again, and the hypocomplement effect could hardly be produced, probably because of the production of CVF antibodies. The use of CVF to create a low complement state in animals to study the pharmacological effects of certain herbal ingredients is a new attempt.