论文部分内容阅读
二丙酸氯地米松(beclomethasone dipropionate,简称Bdp)是一种合成的糖皮质激素,与自然激素有许多方面不同,抗炎作用比氢化考的松大5000倍。本文观察了20名常年性过敏性鼻炎患者应用Bdp治疗后鼻粘膜的超微结构。Bdp使用的日总量为400μg,分4次喷入鼻腔。分别于治疗前、治疗后的第4周、第8周取下鼻甲组织用Corinth 275电镜观察。变态反应过程的消退以如下几点证明:(1)正常的纤毛和微绒毛柱状上皮逐渐修复;(2)细胞间水肿和胞浆空泡消失,表明固有层血管通透性和微循环恢复正常,上皮细胞外形和机械稳定
Beclomethasone dipropionate (referred to as Bdp) is a synthetic glucocorticoid with many different aspects of natural hormones, anti-inflammatory effects than hydrocortisone 5000 times larger. In this paper, we observed the ultrastructure of nasal mucosa in 20 perennial allergic rhinitis patients treated with Bdp. The total daily dose used by Bdp was 400 μg injected into the nasal cavity 4 times. Corona 275 was removed before treatment, at the 4th week and the 8th week after treatment. Corinth 275 was used for electron microscopy. Alleviation of the allergic process was demonstrated by the following: (1) normal cilia and microvilli columnar epithelium gradually repaired; (2) intercellular edema and vacuolar vacuoles disappear, suggesting that lamina propria vascular permeability and microcirculation returned to normal , Epithelial cell shape and mechanical stability