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与发展更好的新镇痛药有关的研究在几个不同方面取得了进展:非甾体类消炎药(NSAIDs)被确认为有效镇痛药,促进了寻找更特异的外周性镇痛药;加强理想口服中枢性镇痛药的寻找,几种有苗头候选药已在进行临床评价;阿片肽及其受体的研究继续广泛开展,现有确凿证据存在两群不同的阿片受体,μ-(吗啡)受体和δ-(脑啡肽)受体,另有充分论据存在第三群阿片受体,κ-受体,这些受体的生理功能未明,但其探索工作很活跃;构-效关系研究集中于发现受体特异性的新镇痛药。临床研究
Research related to developing new and better analgesics has progressed in several different ways: NSAIDs have been identified as potent analgesics, facilitating the search for more specific peripheral analgesics; To enhance the search for ideal oral analgesics, several promising candidate drugs are undergoing clinical evaluation; the research on opioid peptides and their receptors continues to be widespread. There are conclusive evidence that two different groups of opioid receptors, μ- (Morphine) receptors and δ- (enkephalin) receptors, and there is a sufficient argument that there is a third group of opioid receptors, κ-receptors, the physiological function of these receptors is unknown, but its exploration is very active; structure - Efficacy studies have focused on the discovery of receptor-specific new analgesics. Clinical research