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背景与目的 不论抗-HCV检测实验怎么样改进,都存在着这样状况,感染后一段时间才产生抗体,在这期间循环血中存在病毒RNA。作者用HCV早期感染时的样品对一种血清学检测HCV核心抗原的原型实验进行了评估。材料与方法 检测了24例发生HCV血清学转换的患者的连续样品抗-HCV、HCV RNA和HCV核心抗原。结果 83％(20/24)样品HCV抗原与HCV RNA同时被检出。检出HCV抗原的最早平均时间比
BACKGROUND AND OBJECTIVES Regardless of how the anti-HCV test is improved, there is such a condition that antibodies are produced some time after infection during which viral RNA is present in the circulating blood. The authors used a prototype of early HCV infection to evaluate a prototype assay for serological detection of HCV core antigens. MATERIALS AND METHODS Continuous samples of 24 HCV seroconversion patients were tested for anti-HCV, HCV RNA, and HCV core antigens. Results 83% (20/24) samples of HCV antigens were detected simultaneously with HCV RNA. The earliest average time to detect HCV antigens