诺如病毒是引起非细菌性急性感染性胃肠炎的主要病原体,常常引起严重的公共卫生与食品安全问题。诺如病毒疫苗的研发被越来越多的国家提上日程,疫苗的研制和应用依赖于对宿主和病毒相互关系的深入了解,依赖于宿主对病毒的免疫应答机制的了解。本文综述了诺如病毒国内外流行现状、诺如病毒感染与HBGAs受体关系和诺如病毒感染人或动物后机体的免疫应答研究现状。 Norovirus is the major causative agent of non-bacterial acute gastroenteritis and often causes serious public health and food safety problems. The development of Norovirus vaccine is being put on the agenda in more and more countries. The development and application of vaccine relies on a deep understanding of the relationship between host and virus, and depends on the host’s understanding of the immune response mechanism of the virus. This review summarizes the epidemiological status of norovirus at home and abroad, the relationship between norovirus infection and HBGAs receptors and the status of immune response in Norovirus infected human or animal body.