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本文用CEA和Keratin单克隆抗体,对前列腺正常组织、结节性增生和癌各15例进行标记,其中15例前列腺癌随访2年以上,标记方法为BA法。结果,CEA在正常前列腺组织、结节性增生和癌中含量低,阳性率低,提示CEA非识别前列腺癌的理想标记物。Keratin在正常前列腺组织、结节性增生和癌的所有病例中均为阳性。三者在染色强度上无显著差异。不同分化程度的癌在染色强度上也无显著差异。Keratin广泛分布于前列腺癌的上皮细胞内,间质标记均为阴性,对鉴别前列腺上皮性和非上皮性肿瘤是有意义的。
In this paper, CEA and Keratin monoclonal antibody, prostate normal tissue, nodular hyperplasia and cancer in 15 cases were marked, of which 15 cases of prostate cancer were followed up more than 2 years, marked by the BA method. Results, CEA in normal prostate tissue, nodular hyperplasia and low levels of cancer, the positive rate, suggesting that CEA is an ideal marker for non-identification of prostate cancer. Keratin is positive in all cases of normal prostate tissue, nodular hyperplasia and cancer. There was no significant difference in staining intensity among the three. Differentiation of cancer in the staining intensity was no significant difference. Keratin is widely distributed in epithelial cells of prostate cancer, and the interstitial markers are all negative. It is meaningful to differentiate prostate epithelial and non-epithelial tumors.