论文部分内容阅读
目的探讨STK15 Phe31Ile基因多态性与乳腺癌易感性的关系。方法由两名评价员以“STK15/Aurora/BTAK”、“polymorphism”、“SNPs”、“breast cancer”、“Phe31Ile”、“基因多态性”、“乳腺癌”、“易感性”等为主题词分别检索Pubmed、EMbase、SCI、Web of Science、CNKI、VIP、万方等中英文数据库,未进行语种限制。对所获文献进行质量评价、筛选和提取相关病例对照研究资料,并以OR值及95%可信区间为效应指标,对照组基因型频数分布均符合Hardy-Weinberg遗传平衡定律。利用Stata10.0软件进行Meta分析。结果最终纳入7项病例对照研究进行Meta分析,其中病例组5615例,对照组7539例。以STK15 Phe/Phe或Phe/Ile基因型携带者为参照,携带Ile/Ile基因型的个体患乳腺癌的风险显著增加,(OR=1.23,95%CI=1.00-1.50)。结论 STK15 Phe31Ile位点多态性与乳腺癌易感性相关,Ile/Ile基因型为乳腺癌的易感基因型。
Objective To investigate the relationship between STK15 Phe31Ile polymorphism and the susceptibility to breast cancer. Methods Two reviewers named “STK15 / Aurora / BTAK”, “polymorphism”, “SNPs”, “breast cancer”, “Phe31le”, “ PubMed, EMbase, SCI, Web of Science, CNKI, VIP, Wanfang and other Chinese and English databases were searched with the keywords of ”Breast Cancer“ and ”Susceptibility" respectively. The quality of the literature was evaluated, the relevant case-control data were screened and extracted, and the OR and 95% confidence intervals were used as effect indicators. The frequency distribution of genotypes in the control group all accorded with the Hardy-Weinberg law of genetic balance. Meta-analysis was performed using Stata 10.0 software. Results Finally, seven case-control studies were included in the meta-analysis, of which 5615 were in the case group and 7539 in the control group. Individuals with the Ile / Ile genotype had a significantly increased risk of breast cancer with STK15 Phe / Phe or Phe / Ile genotype carriers (OR = 1.23, 95% CI = 1.00-1.50). Conclusion The polymorphism of Phe31Ile in STK15 is associated with susceptibility to breast cancer. The genotype of Ile / Ile is predisposing to breast cancer.