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目的评价综合干预对代谢综合征高危人群心血管危险因素影响。方法对经常住院的100例代谢综合征高危患者进行综合干预,随访2年。另选一般临床资料相匹配,具有可比性的60例代谢综合征高危患者作对照组,评估综合干预前后即第0,1,2年腰围、体重指数、收缩压和舒张压、HDL-C、TG、LDL-C、空腹血糖、空腹胰岛素、胰岛素抵抗指数、C-反应蛋白的变化,并进行对照。结果干预组0年,1年,2年的比较,腰围、BMI、SBP和DBP、HDL-C、FBG、HOMA-IR、CRP的变化差异有统计学意义(P<0.05),而TG和LDL-C变化差异无统计学意义(P>0.05);对照组0年,1年,2年的比较,腰围、BMI、SBP和DBP、HDL-C、TG、LDL-C、FBG、FINS、HOMA-IR、CRP的变化差异均无统计学意义(P>0.05);干预组与对照组两组第2年比较,除TG和LDL-C外,腰围、BMI、SBP和DBP、HDL-C、FBG、HOMA-IR、CRP的变化差异有统计学意义(P<0.05)。结论综合干预可改善代谢综合征胰岛素抵抗,提高胰岛素敏感性,降低CRP。
Objective To evaluate the effect of comprehensive intervention on cardiovascular risk factors in high risk population with metabolic syndrome. Methods A total of 100 high-risk patients with metabolic syndrome who were hospitalized frequently were followed up for 2 years. Another 60 patients with high-risk metabolic syndrome with comparable clinical data were selected as the control group to evaluate the changes of waist circumference, body mass index, systolic and diastolic blood pressure, HDL-C, TG, LDL-C, fasting blood glucose, fasting insulin, insulin resistance index, C-reactive protein changes, and control. Results The changes of waist circumference, BMI, SBP and DBP, HDL-C, FBG, HOMA-IR and CRP in the intervention group at 0, 1 and 2 years were significantly different (P <0.05) (P> 0.05). The changes of waist circumference, BMI, SBP and DBP, HDL-C, TG, LDL-C, FBG, FINS and HOMA in the control group at 0, 1 and 2 years (P> 0.05). Compared with TG and LDL-C, waist circumference, BMI, SBP and DBP, HDL-C, FBG, HOMA-IR, CRP changes were statistically significant (P <0.05). Conclusion Comprehensive intervention can improve insulin resistance of metabolic syndrome, improve insulin sensitivity and reduce CRP.