肿瘤抑制基因ｎｍ２３Ｈ１的低表达和层粘素受体Ｌａｍｉｎｉｎｒｅｃｅｐｔｏｒ，ＬＮＲ高表达在肿瘤中的作用日益受到重视。我们应用ＳＰ免疫组织化学方法探讨ｎｍ２３Ｈ１和ＬＮＲ的表达变化与胆管癌组织学类型、分化程度及淋巴结转移之间的关系，报告如下。１材 The low expression of tumor suppressor gene nm23H1 and the high expression of laminin receptor, LNR in tumors have attracted increasing attention. We applied SP immunohistochemical methods to investigate the relationship between the expression of nm23-H1 and LN-R and the histological type, differentiation and lymph node metastasis of cholangiocarcinoma, as reported below. 1 material