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小肠是电离辐射的敏感组织．γ射线照射后小肠上皮干细胞的损伤，肠道组织形态和生理功能改变的文献报道较多［１］，但肠道辐射损伤分子机制的研究尚未见报道．我们采用ｍＲＮＡ差异展示技术，分离正常的和经６０Ｃｏγ射线照射的人肠上皮细胞株ＨＩＥＣ细胞的差异表达基因，?
Small intestine is sensitive to ionizing radiation. There are many reports on the changes of intestinal epithelial stem cells, intestinal morphology and physiological functions after γ-ray irradiation [1]. However, the molecular mechanisms of intestinal radiation damage have not been reported yet. We used mRNA differential display technique to separate differentially expressed genes from normal and 60Coγ-ray-irradiated human intestinal epithelial cell line HIEC cells.