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目的 探讨宫颈鳞癌患者血清鳞状上皮细胞癌抗原 (SCCAg)的检测及其临床意义。方法 采用微粒子酶免疫分析法检测 12 4例宫颈鳞癌患者治疗前血清SCCAg值。早期患者 (Ⅰ～Ⅱa期 )术后 1周重复检测 ,部分手术患者随诊中监测。 结果 宫颈鳞癌血清SCCAg检测的敏感性为 73 .4% ,特异性为 96 .1%。SCCAg阳性率随临床分期进展而增高 ,有非常显著性差异 (P <0 .0 1) ,早期患者术前SCCAg异常者术后均下降至正常水平 ,有非常显著性差异 (Ⅰa期P <0 .0 1,Ⅰb +Ⅱa期P <0 .0 1)。部分术后患者随诊中血清SCCAg值在正常水平。 结论 SCCAg是宫颈鳞癌较特异的肿瘤标志物 ,可以作为宫颈癌辅助诊断指标 ,评价宫颈癌手术疗效 ,在早期宫颈鳞癌中的临床意义值得进一步研究。
Objective To investigate the detection of serum squamous cell carcinoma antigen (SCCAg) in patients with cervical squamous cell carcinoma and its clinical significance. Methods Serum SCCAg levels of 12 4 patients with cervical squamous cell carcinoma before treatment were detected by microparticle enzyme immunoassay. Early patients (Ⅰ ~ Ⅱ a) repeated 1 week after surgery, some patients were monitored during follow-up. Results The sensitivity and specificity of serum SCCAg in cervical squamous cell carcinoma were 73.4% and 96.1% respectively. The positive rate of SCCAg increased with the clinical stage, there was a significant difference (P <0.01). In early stage, the patients with abnormal SCCAg before operation decreased to the normal level after operation, with significant difference (P <0 .0 1, Ⅰb + Ⅱ a stage P <0. 01). Some postoperative patients with serum SCCAg value at the normal level. Conclusion SCCAg is a specific tumor marker of cervical squamous cell carcinoma, which can be used as an auxiliary diagnostic indicator of cervical cancer to evaluate the curative effect of cervical cancer. The clinical significance of SCCAg deserves further study in early cervical squamous cell carcinoma.