目的　观察 6 1例原发性肝癌合并门脉癌栓患者的治疗效果。方法　 A组 (36例 )行肝动脉化疗栓塞(TACE)治疗 ,B组 (2 5例 )行 TACE结合外放射综合治疗 ,两组一般临床资料无显著差异 (P>0 .0 5 )。结果　 A组1、2年生存率分别为 2 2 .3%、4.5 % ,平均生存期 7.5个月 ;B组 1、2、3年生存率分别为 39.2 %、2 1.2 %、17.2 % ,平均生存期 13.5个月 ,两组差异有显著性 (P<0 .0 5 )。结论　对合并门脉癌栓的肝癌应积极治疗 ,综合治疗能明显提高治疗效果。 Objective To observe the therapeutic effect of 61 patients with primary hepatocellular carcinoma combined with portal cancer thrombus. Methods TACE was performed in group A (36 patients) and TACE combined with external radiotherapy in group B (25 patients). There was no significant difference between the two groups in clinical data (P>0.05). Results The 1-year and 2-year survival rates in group A were 22.3% and 4.5%, respectively, and the average survival time was 7.5 months. The 1-, 2-, and 3-year survival rates in group B were 39.2%, 2 1.2%, and 17.2%, respectively. The survival time was 13.5 months. There was a significant difference between the two groups (P<0.05). Conclusion Liver cancer with portal vein tumor thrombus should be actively treated, and comprehensive treatment can significantly improve the therapeutic effect.