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目的探究桂枝茯苓胶囊联合抗生素治疗慢性盆腔炎患者的疗效及对C反应蛋白(CRP)、白细胞介素-2(IL-2)及肿瘤坏死因子-α(TNF-α)的影响。方法选取2014年5月—2016年1月焦作市解放军91中心医院接收的符合研究标准的106例慢性盆腔炎患者,根据用药方案不同分为对照组53例和观察组53例。对照组采用青霉素及甲硝唑等常规抗生素药物,观察组在对照组用药基础上加用桂枝茯苓胶囊,两组均持续治疗21 d。对比两组治疗前及治疗后21 d两组血清炎性因子CRP、IL-2、TNF-α水平变化情况,并于治疗后3个月对两组患者进行随访,统计疾病复发率及不良反应发生率。结果观察组治疗有效率92.46%高于对照组75.47%,疾病复发率5.66%低于对照组20.75%,差异有统计学意义(P<0.05)。治疗前两组CRP、IL-2、TNF-α水平比较,差异无统计学意义(P>0.05);经治疗,观察组各指标明显优于对照组,差异有统计学意义(P<0.05);两组均未出现不良反应。结论桂枝茯苓胶囊联合抗生素治疗慢性盆腔炎效果显著,可有效改善血清炎性因子水平,降低疾病复发率。
Objective To investigate the effects of Guizhi Fuling Capsule combined with antibiotics in the treatment of patients with chronic pelvic inflammatory disease and the effects of C-reactive protein (CRP), interleukin-2 (IL-2) and tumor necrosis factor-α (TNF- α). Methods From May 2014 to January 2016, 106 patients with chronic pelvic inflammatory disease who met the research criteria received by 91 Central Hospital of Jiaozuo City of Jiaozuo were divided into control group (n = 53) and observation group (n = 53) according to different dosage regimen. The control group used penicillin and metronidazole and other conventional antibiotics, the observation group in the control group based on the use of Guizhi Fuling capsule, two groups were treated for 21 days. The levels of serum inflammatory cytokines CRP, IL-2 and TNF-α in two groups before and 21 days after treatment were compared. The two groups were followed up 3 months after treatment, and the relapse rate and adverse reactions were calculated Occurrence rate. Results The effective rate of observation group was 92.46% higher than that of control group 75.47%, disease recurrence rate 5.66% lower than that of control group 20.75%, the difference was statistically significant (P <0.05). There was no significant difference in the levels of CRP, IL-2 and TNF-α between the two groups before treatment (P> 0.05). After treatment, the indexes in the observation group were significantly better than those in the control group (P <0.05) ; No adverse reaction was found in both groups. Conclusion Guizhi Fuling capsules combined with antibiotics in the treatment of chronic pelvic inflammatory disease significantly, which can effectively improve serum levels of inflammatory cytokines and reduce the recurrence rate.