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目的评价中性粒细胞脂钙素(HNL)和降钙素原(PCT)的检测对儿童急性细菌性呼吸道感染的诊断价值。方法76例5d~14岁伴有急性呼吸道感染(ARI)症状的儿童患者,检测血清HNL和PCT含量,并与ARI常规诊断指标CRP、WBC和ESR进行比较,运用受试者工作特性曲线(ROC)评价上述各指标对诊断儿童细菌性ARI的价值。结果细菌感染组HNL、PCT、CRP、WBC和ESR显著高于病毒感染组(P<0.01),上述各指标的AUC分别为0.903(95%CI:0.813～0.959),0.987(95%CI:0.930～0.998),0.962(95%CI:0.891～0.992),0.839(95%CI:0.736～0.921)以及0.891(95%CI:0.798～0.951)。结论HNL和PCT对儿童ASI的诊断价值与CRP相当,但优于WBC、ESR。
Objective To evaluate the diagnostic value of detection of neutrophil calcitonin (HNL) and procalcitonin (PCT) in children with acute bacterial respiratory tract infection. Methods Seventy-six pediatric patients with acute respiratory infection (ARI) symptoms of 5 to 14 years old were enrolled in this study. Serum HNL and PCT levels were measured and compared with CRI, WBC and ESR, routine diagnostic indexes of ARI. The receiver operating characteristic curve (ROC ) Evaluation of the above indicators for the diagnosis of bacterial ARI in children. Results The HNL, PCT, CRP, WBC and ESR in bacterial infection group were significantly higher than those in viral infection group (P <0.01). The AUC of the above indexes were 0.903 (95% CI: 0.813-0.959), 0.987 To 0.998), 0.962 (95% CI: 0.891 to 0.992), 0.839 (95% CI: 0.736 to 0.921) and 0.891 (95% CI: 0.798 to 0.951). Conclusion The diagnostic value of HNL and PCT in children with ASI is similar to CRP, but superior to WBC and ESR.