关于外源性表面活性剂疗法的实验已有多次报道。对早产儿首次应用后的二十年中,这方面的实验一直没有间断,但至今没有取得一致的评价。由于各家实验的方法有所不同,彼此之间难以作出比较,争论还是相当激烈的。决定这一差异的因素,可能是所采用的物质不同,这些物质包括从羊水、乳牛及其他动物肺脏洗涤液中提取的一种磷脂混合物,有时也用综合性磷脂及完全合成的磷脂补充,或是用纯净的双十六(烷)酰磷脂胆硷或其与磷脂酸甘油的结合物。 Experiments on exogenous surfactant therapy have been reported many times. In the two decades after the first application of premature babies, there has been no interruption of experiments in this area, but so far no consistent assessment has been made. Due to the different methods of experiments, it is hard to make a comparison with each other, and the debate is quite fierce. The factors that determine this discrepancy may be the substances used, which include a mixture of phospholipids extracted from amniotic fluid, dairy cows and other animal lung washes, sometimes supplemented with synthetic phospholipids and fully synthesized phospholipids, or Is pure dihexadecylphospholipid choline or its combination with phosphatidic glycerol.