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目的通过回顾性研究分析重庆市渝中区2005-2012年围产儿出生缺陷的发生情况及变化趋势,为病因学研究提供线索,为孕前优生、遗传咨询、预防和降低出生缺陷再发风险提供参考依据,进一步提高出生人口素质。方法依据《中国出生缺陷监测方案》和《重庆市妇幼卫生监测方案》,对2005-2012年渝中区常住人口中分娩的围产儿进行监测,并分析主要指标。结果监测2005-2012年围产儿34 494例,出生缺陷592例,总出生缺陷发生率17.16‰。出生缺陷前3位依次为先天性心脏病、多指(趾)和唇腭裂。结论出生缺陷的水平和顺位与产前筛查和产前诊断等措施密切相关,通过进一步加强健康教育,做好婚前保健、孕产期保健,提高产前筛查及产前诊断水平,可降低围产儿出生缺陷的发生。
OBJECTIVE: To provide a clue for the etiological study by retrospectively analyzing the incidence and trend of birth defects in Yuzhong District from 2005 to 2012 in Chongqing, and to provide a reference for prenatal eugenics, genetic counseling, prevention and reduction of the risk of recurrence of birth defects , To further improve the quality of the birth population. Methods According to “China Birth Defects Monitoring Program” and “Chongqing Municipal Maternal and Child Health Surveillance Program”, the perinatal children born in the resident population of Yuzhong District during 2005-2012 were monitored and the main indicators were analyzed. Results From 2005 to 2012, 34 494 cases of perinatal children were monitored. 592 cases of birth defects were observed. The total incidence of birth defects was 17.16 ‰. The first three birth defects followed by congenital heart disease, multiple fingers (toes) and cleft lip and palate. Conclusions The level and sequence of birth defects are closely related to prenatal screening and prenatal diagnosis. By further strengthening health education, prenuptial health care, maternal health care, prenatal screening and prenatal diagnosis can be reduced Perinatal birth defects.