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观察和平散对消炎痛所致大鼠胃粘膜损伤的保护作用 ,采用肌肉注射消炎痛 ( 2 0mg/kg)胃粘膜损伤模型 ,观察和平散 (潞党参、五味子、陈皮等 ) 3个剂量组和对照组的损伤指数 ,并同时检测血清和胃组织匀浆的超氧化物歧化酶 (SOD)活力和丙二醛 (MDA)含量。结果发现和平散各剂量组的胃粘膜损伤指数均较对照组明显减轻 (P <0 0 1及P <0 0 0 1) ,且具有剂量依赖性 ,三倍量组的抑制率达 94 % ;和平散可明显提高血清和胃组织的SOD活力 ,降低其MDA含量。说明和平散可显著抑制消炎痛所致胃粘膜损伤 ,其作用机制可能与抗氧化损伤有关。
Observing Heping Powder on the protective effect of indomethacin-induced gastric mucosal injury in rats, using intramuscular injection of indomethacin (20 mg/kg) gastric mucosal injury model, observing 3 doses of Heping Powder (Dangshen, Schisandra, Citrus, etc.) The injury index of the control group was measured simultaneously with superoxide dismutase (SOD) activity and malondialdehyde (MDA) content in the serum and stomach tissue homogenates. The results showed that the scores of gastric mucosal injury were significantly reduced in the Heping Powder group compared with the control group (P <0 01 and P <0 0 01), and it was dose-dependent. The inhibition rate of the triple dose group was 94%. Heping Powder can significantly increase SOD activity in serum and stomach tissue and reduce its MDA content. It shows that Heping Powder can significantly inhibit the gastric mucosal damage caused by indomethacin, and its mechanism of action may be related to antioxidative damage.