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为探讨终末期肾功能衰竭病人血液透析过程中免疫功能改变，采用改良ＥｓｎａｕｌｔＳ法进行外周血单个核细胞分离及培养与酶联免疫吸附（ＥＬＩＳＡ）法检测，对１２例终末期肾衰病人在采用不同透析膜血透时，外周血单个核细胞培养上清中白细胞介素１３（ＩＬ－１３）的水平进行观察。发现血透前ＩＬ－１３与正常对照无明显差异，而血透后ＩＬ－１３水平明显降低，但不同透析膜对ＩＬ－１３的影响无显著差异。提示在终末期肾衰病人的血透过程中，存在Ｔｈ２细胞的功能受损
In order to explore the immune function changes during hemodialysis in patients with end-stage renal failure, peripheral blood mononuclear cells were isolated and cultured by modified EsnaultS method and detected by enzyme-linked immunosorbent assay (ELISA). In 12 patients with end-stage renal failure The levels of interleukin-13 (IL-13) in peripheral blood mononuclear cell culture supernatants were observed when hemodialysis was performed on different dialysis membranes. It was found that IL-13 before hemodialysis had no significant difference with normal control, while the level of IL-13 decreased significantly after hemodialysis. However, the effect of different dialysis membranes on IL-13 had no significant difference. This suggests that in the process of hemodialysis in patients with end-stage renal failure, Th2 cells are impaired in their function