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本试验采用饲喂试验兔高脂饲料的方法制备高脂血症动物模型,其目的在于探索兔外源性高脂血症模型的制作方法。试验结果显示:模型组兔在饲喂高脂饲料后出现精神萎靡、被毛蓬乱、粪便稀湿等现象;模型组兔的肝脏指数明显升高,与空白组相比差异极显著(P<0.01);模型组兔血清中的胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)均显著升高,与空白组相比差异极显著(P<0.01)。说明饲喂试验兔高脂饲粮能够制作外源性高脂血症动物模型。
In this study, the animal model of hyperlipidemia was prepared by feeding high-fat diet of experimental rabbits. The purpose of this study was to explore the method of making exogenous hyperlipidemia model in rabbits. The results showed that: the model group of rabbits fed with high-fat diet appeared apathetic, disheveled hair, wet stool and other phenomena; the model group rabbits liver index was significantly increased, compared with the blank group, the difference was significant (P <0.01 (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) in model group were significantly higher than those in blank group (P <0.01). Explain that feeding high-fat diet rabbits can produce exogenous hyperlipidemia animal model.