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吸入一氧化氮对肺血管具有选择性扩张作用,而对体循环无明显作用。对于急性呼吸窘迫综合征(ARDS)患者,吸入一氧化氮具有改善氧合和降低肺动脉压的作用,已被大量的实验和临研究证实。但是吸入一氧化氮对ARDS病程及预后的影响尚不完全清楚。本研究采用多中心、随机、前瞻性的控制性开放配对研究方法,给予ARDS患者早期、持续性的吸入一氧化氮,观察持续性一氧化氮吸入是否能够使提高一氧化氮对急性肺损伤的改善率,同时观察吸入一氧化氮对ARDS严重程度和患者预后的影响。
Inhaled nitric oxide has a selective expansion of the pulmonary vasculature, but no significant effect on the systemic circulation. In patients with acute respiratory distress syndrome (ARDS), inhalation of nitric oxide has the effect of improving oxygenation and reducing pulmonary arterial pressure, which has been confirmed by a large number of experimental and clinical studies. However, the impact of inhaled nitric oxide on the course and prognosis of ARDS is not fully understood. In this study, a multicenter, randomized, prospective controlled open pair study was conducted to provide early and sustained inhaled nitric oxide to patients with ARDS and to investigate whether persistent nitric oxide inhalation can enhance the effects of nitric oxide on acute lung injury Improve the rate, at the same time observe the inhalation of nitric oxide on the severity of ARDS and the prognosis of patients.