对青霉素的耐药性是否会影响对肺炎球菌感染的治疗,大部分取决于耐药的程度和感染的部位,对青霉素有任何程度不敏感的肺炎球菌所致的脑膜炎,即使用大剂量的青霉素治疗也伴有不良的效果和高死亡率。这种结局几乎肯定地是由于青霉素进入脑脊液较少,结果是青霉素浓度低于或接近耐药菌株的最低抑制浓度(MIC)。因此寻求其他可供选择的疗法治疗 Whether resistance to penicillin affects the treatment of pneumococcal infections depends in large part on the extent of drug resistance and the site of infection, pneumococcal meningitis with any degree of insensitivity to penicillin, even at high doses Penicillin treatment is also associated with poor efficacy and high mortality. This outcome is almost certainly due to less penicillin into the cerebrospinal fluid resulting in a lower inhibitory concentration (MIC) of penicillin at or below the drug-resistant strain. So look for other alternative therapies